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In people with CAD, a combination of high cholesterol levels and other fats in the blood collects on the inner lining of the heart's arteries, eventually forming a thick plaque that attracts clotting agents in the blood. Once a clot forms, it's very difficult for blood to get to the heart. That's when a heart attack occurs -- cells in the oxygen-depleted heart start to die, and the heart falters. For some people, heart disease is out of their control, a result of genetics or diabetes \ No newline at end of file